How Natural Killer Cells Target Cancer Without Prior Sensitization
The human immune system is remarkably intelligent, with multiple layers of defense working together to protect the body from disease. Among these defenders, Natural Killer cells stand out for their unique ability to recognize and destroy cancer cells without prior sensitization. Unlike T cells, which require specific antigen recognition, NK cells act swiftly and instinctively—making them a powerful focus in modern cancer immunotherapy and cell and gene therapy research. Understanding Natural Killer Cells Natural Killer cells are a critical component of the innate immune system, serving as the body’s first line of defense against abnormal cells. They are named for their ability to “naturally” eliminate target cells without the need for prior exposure or immune memory. This makes NK cells particularly effective against tumor cells and virus-infected cells, which often evade other immune mechanisms. NK cells circulate in the bloodstream and tissues, constantly surveying for signs of...